Effect of Recombinant Human Granulocyte Colony Stimulating Factor on Lymphocyte Blastogenesis in Healthy Dogs.

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  • HASEGAWA Takashi
    Veterinary Teaching Hospital,Faculty of Agriculture,Miyazaki University,1-1 Nishi,Gakuen-Kibanadai,Miyazaki 889-2192,Japan
  • INOMATA Takateru
    Veterinary Teaching Hospital,Faculty of Agriculture,Miyazaki University,1-1 Nishi,Gakuen-Kibanadai,Miyazaki 889-2192,Japan

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  • 臨床病理学:健常犬のリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子の影響(短報)

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Abstract

Effects of recombinant human granulocyte colony−stimulating factor(rhG−CSF)on the number and blastogenesis of lymphocytes were evaluated in clinically healthy dogs treated subcutaneously with rhG−CSF at a dose of 2.5 μg/kg for 3 days.Significant increases in the number of leukocytes and segmented neutrophils were observed after the administration of rhG−CSF.The number of lymphocytes also increased on days 1 and 2 after the treatment.Activities of phytohemagglutinin, concanavalin A, and pokeweed mitogen−induced lymphocyte blastogenesis(LB)were augmented to twice the pretreatment levels by the administration of rhG−CSF.These results suggested that administration of rhG−CSF activated lymphocyte functions such as LB in healthy dogs.

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