血液動態で裏打ちされるBabesia microtiに対するジャンガリアンハムスター(Phodopus sungorus)の高感受性

DOI 日本農学文献記事索引 Web Site Web Site PubMed 参考文献34件
  • IKE Kazunori
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • KOMATSU Tetsuya
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • MURAKAMI Takashi
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • KATO Yousuke
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • TAKAHASHI Miwa
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • UCHIDA Yuko
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University
  • IMAI Soichi
    Department of Veterinary Parasitology, Nippon Veterinary and Animal Science University

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タイトル別名
  • High Susceptibility of Djungarian Hamsters (Phodopus sungorus) to the Infection with Babesia microti Supported by Hemodynamics

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As the comparative study was carried out on the susceptibility by the pursuit of parasitemia among the Djungarian, Syrian, and Chinese hamsters as well as BALB/c mice infected with the Syrian hamster-adapted Babesia microti strain, and Djungarian hamsters showed the highest parasitemia among them. Then, the other hematological parameters were pursued in the Djungarian hamsters infected with the hamster-adapted B. microti strain. Remarkable symptoms observed were hemoglobinuria clinically, anemia hematologically, and splenomegaly macroscopically during all over the observation period for 24 weeks post infection (PI). Parasitemia began to rise at 2 weeks and peaked at 4 weeks PI. After that, parasitemia decreased gradually but was maintained with a level of about 10% on average until 24 weeks PI at the end of the experiment. A decrease in the RBC count, Hb, and PCV, and an increase in the reticulocyte and WBC counts due to the development of immature neutrophils, lymphocytes and monocytes were recognized together with a rise of parasitemia. The hamsters had macrocytic hypochromic anemia due to the increase of MCV and the decrease of MCHC in the growth phase of the parasite. It was considered that the Djungarian hamsters will be useful for the infection examination, isolation, maintenance, and passage of B. microti in laboratory.<br>

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