Susceptibility of Liver Proliferative Lesions in Heterozygous p53 Deficient CBA Mice to Various Carcinogens.

DOI Web Site Web Site PubMed 被引用文献2件 参考文献28件
  • UEHARA Takeki
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
  • KASHIDA Yoko
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
  • WATANABE Takao
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
  • YASUHARA Kazuo
    Division of Pathology, National Institute of Health Sciences
  • ONODERA Hiroshi
    Division of Pathology, National Institute of Health Sciences
  • HIROSE Masao
    Division of Pathology, National Institute of Health Sciences
  • MITSUMORI Kunitoshi
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology Division of Pathology, National Institute of Health Sciences

この論文をさがす

説明

To investigate the liver tumorigenic sensitivity to various carcinogens in heterozygous p53 deficient [p53 (+/-)] CBA mice and their wild-type littermates [p53 (+/+) mice], 71 p53 (+/-) and 74 p53 (+/+) CBA mice (male, 6-12 weeks of age) were given diet containing 4,000 or 0 ppm flumequine (FL) for 26 weeks or a single intraperitoneal injection of 5 mg/kg body weights dimethylnitrosamine (DMN) at start of the study in Exp. 1, diet containing 6,000 or 0 ppm di(2-ethylhexyl)-phthalate (DEHP) for 26 weeks in Exp. 2, or diet containing 12,000, 6,000 or 0 ppm phenolphthalein (PhP) for 26 weeks in Exp. 3. All surviving animals of these groups were killed after completion of treatment of the test substances for 26 weeks. In the FL groups, the incidences of hepatocellular altered foci in p53 (+/-) mice, the multiplicities of those in p53 (+/-) and p53 (+/+) mice were significantly increased as compared to the corresponding control groups. The incidences and multiplicities of altered foci in the DMN groups were higher than those in the corresponding control groups in p53 (+/-) and p53 (+/+) mice, but no significant differences were indicated between the groups. There were no significant differences in the incidences, multiplicities and proliferating cell nuclear antigen labeling indices of altered foci in the FL or DMN groups between p53 (+/-) and p53 (+/+) mice. There were no significant differences in the incidences and multiplicities of altered foci between the DEHP or PhP and control groups. The present results suggest that p53 gene knocked out heterozygously does not enhance the chemical hepatocarcinogenesis in CBA mice.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ