Epitope Mapping of a Monoclonal Antibody Specific to Feline Panleukopenia Virus and Mink Enteritis Virus.

  • HORIUCHI Motohiro
    Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine
  • MOCHIZUKI Masami
    Laboratory of Clinical Microbiology, Kyoritsu Shoji Co.
  • ISHIGURO Naotaka
    Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine
  • NAGASAWA Hideyuki
    Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine
  • SHINAGAWA Morikazu
    Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine

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説明

To obtain monoclonal antibodies (MAbs) specific to feline panleukopenia virus (FPLV) and mink enteritis virus (MEV), 15 hybridomas secreting MAbs against MEV-Abashiri were established and the properties of the MAbs were analyzed. The cross-reactivity of MAbs revealed that one MAb, P2-215 was specific for FPLV and MEV, whereas the remaining fourteen MAbs reacted with canine parvovirus (CPV), FPLV, and MEV. Epitope analyses using various CPV/MEV chimeric viruses revealed that the MAb P2-215 recognized the epitope comprised of amino acid 93-Lys in VP2, which is known to be FPLV and MEV-specific.

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