Epitope Mapping of a Monoclonal Antibody Specific to Feline Panleukopenia Virus and Mink Enteritis Virus.
-
- HORIUCHI Motohiro
- Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine
-
- MOCHIZUKI Masami
- Laboratory of Clinical Microbiology, Kyoritsu Shoji Co.
-
- ISHIGURO Naotaka
- Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine
-
- NAGASAWA Hideyuki
- Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine
-
- SHINAGAWA Morikazu
- Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine
この論文をさがす
説明
To obtain monoclonal antibodies (MAbs) specific to feline panleukopenia virus (FPLV) and mink enteritis virus (MEV), 15 hybridomas secreting MAbs against MEV-Abashiri were established and the properties of the MAbs were analyzed. The cross-reactivity of MAbs revealed that one MAb, P2-215 was specific for FPLV and MEV, whereas the remaining fourteen MAbs reacted with canine parvovirus (CPV), FPLV, and MEV. Epitope analyses using various CPV/MEV chimeric viruses revealed that the MAb P2-215 recognized the epitope comprised of amino acid 93-Lys in VP2, which is known to be FPLV and MEV-specific.
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 59 (2), 133-136, 1997
公益社団法人 日本獣医学会