鳥類ボツリヌス症に対するボツリヌスC/Dモザイクトキソイドの防御効果

  • TAKEDA Masato
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • KASAI Hiroko
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • TORII Yasushi
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • MUKAMOTO Masafumi
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • KOHDA Tomoko
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • TSUKAMOTO Kentaro
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • KOZAKI Shunji
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

書誌事項

タイトル別名
  • Protective Effect of Botulinum C/D Mosaic Toxoid against Avian Botulism

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抄録

Avian botulism is a paralytic disease caused by a toxin produced by Clostridium botulinum type C. Since type C isolates from cases of avian botulism produced a neurotoxin consisting of a mosaic form of parts of type C and D neurotoxins, we examined the antitoxin titers in the convalescent sera of botulism-affected birds which belonged to family Anatidae. ELISA using the C/D mosaic neurotoxin as an antigen revealed that the antibody was detected in the sera at 2 weeks, but not at 5 weeks after the onset, suggesting that the antibody only appeared for a short period in the convalescent phase. However, we failed to detect the antibody titers with anti-chicken IgG instead of anti-duck IgG. We therefore examine the immunological properties of IgG among different families and species. The results revealed that different species of IgG in the same family exhibited strong cross-reactivity. Ducks immunized once with the toxoid together with a commercial oil-adjuvanted vaccine were found to develop sufficient antibody to protect against a challenge with a lethal toxin dose. The ELISA titers did not correspond to the neutralization titers in the sera of immunized ducks at the early stage during immunization. These findings suggest that the neutralizing titer was more useful than the ELISA titer for evaluating the protection against the toxin, but the ELISA technique may be applicable for detecting the occurrence of botulism.<br>

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