Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats.
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- OKAZAKI Yoshimasa
- Mitsubishi Chemical Safety Institute Ltd.
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- YAMASHITA Kotaro
- Mitsubishi Chemical Safety Institute Ltd.
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- SUDO Masato
- Mitsubishi Chemical Safety Institute Ltd.
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- TSUCHITANI Minoru
- Mitsubishi Chemical Safety Institute Ltd.
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- NARAMA Isa
- Research Institute of Drug Safety, Setsunan University
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- YAMAGUCHI Ryoji
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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- TATEYAMA Susumu
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
Bibliographic Information
- Other Title
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- アニリンをラットに単回経口投与することで誘発される神経毒性
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Abstract
The neurotoxicity of aniline and its age-dependent responses were investigated in male rats. Groups of 6 rats, 4-week-old, were treated once with aniline (500, 750 or 1,000 mg/kg) or olive oil by gavage. Additional groups of 6 rats, 7- or 10-week-old, were treated once with 800 mg/kg of aniline or olive oil. Paralytic gait or hindlimb paralysis was observed between post-treatment days 8 and 15 in two out of six rats receiving 1,000 mg/kg of aniline at 4 weeks of age. On post-treatment day 15, spongy change in the white matter of the spinal cord was observed in all rats receiving 750 or 1,000 mg/kg of aniline at 4 weeks of age. The lateral and ventral columns of the thoracic spinal cord were the most severely affected. Spongy change in the facial nerve and spinal trigeminal tracts of pons and medulla oblongata, and mild degeneration of the peripheral nerves was found in 3 out of 6 rats receiving 1,000 mg/kg of aniline. At the ultrastructural level, the spongy change was due to distention of the myelin sheath and splitting of the intraperiod line. Axons were well preserved in the affected nerve fibers. No abnormalities were seen in the neuronal cell bodies. Although transient cyanosis was observed in all rats receiving 800 mg/kg of aniline at 7- or 10-week-old, as well as in rats receiving 750 or 1,000 mg/kg of aniline at 4-week-old, no treatment-related neurobehavioral or morphologic abnormalities were found in the former. These findings demonstrate the neurotoxicity of orally administered aniline for rats, depending upon the age of the animal at the time of administration.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 63 (5), 539-546, 2001
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206425882240
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- NII Article ID
- 110003920647
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- NII Book ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXkslGqt70%3D
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 10458/1180
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- NDL BIB ID
- 5773867
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- PubMed
- 11411500
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed