Lymphoproliferative Responses in Pigs Infected with Mycobacterium avium.

  • IWAKIRI Akira
    Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University
  • TOSHIMASU Miho
    Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University
  • XU De Long
    Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University
  • SHINJO Toshiharu
    Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University
  • GOTO Yoshitaka
    Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University

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抄録

Naturally infected cases of swine mycobacteriosis were divided into two groups, localized infection (LI) and disseminated infection (DI). Lymphoproliferative response (LPR) was then examined to estimate their immunological states. Both control and LI groups showed strong response to Concanavalin A (Con A) and phytohemagglutinin (PHA) in the LPR, and lymphocytes recovered from the LI responded well to purified protein derived from M. avium (PPD). On the other hand, the DI group showed weak response to both Con A and PHA, despite their strong response to PPD stimulation. These data suggest that the low LPR to Con A and PHA observed in the DI groups was probably not due to the general unresponsiveness of T-cells.

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