Platelet Dysfunction in Chediak-Higashi Syndrome-Affected Cattle.
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- SHIRAISHI Mitsuya
- Department of Veterinary Pharmacology, Faculty of Agriculture, Miyazaki University
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- OGAWA Hiroyuki
- Graduate School of Agriculture and Life Science, The University of Tokyo, Tokyo
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- IKEDA Masahiro
- Department of Veterinary Pharmacology, Faculty of Agriculture, Miyazaki University
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- KAWASHIMA Sachiko
- Department of Veterinary Pharmacology, Faculty of Agriculture, Miyazaki University
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- ITO Katsuaki
- Department of Veterinary Pharmacology, Faculty of Agriculture, Miyazaki University
Bibliographic Information
- Other Title
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- チェディアック・東症候群の牛における血小板機能異常
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Abstract
A serious symptom of cattle affected with Chediak-Higashi syndrome (CHS) is a bleeding tendency. This diathesis is characterized by insufficient platelet aggregation as a result of depressed response to collagen. One possible cause for the depression is a decrease in contribution of endogenous agonists such as ADP or thromboxane A2, which are released following collagen stimulation. However, these endogenous agonists play only a minor role in collagen-induced aggregation of bovine platelets. More importantly, activation of phospholipase C as a result of a direct action of collagen is depressed, leading to a depression of Ca2+ mobilization, in platelets from CHS-affected cattle. Several types of collagen receptor are proposed to work in concert to induce aggregation. Among them, glycoprotein VI (GPVI) and GPIa/IIa (integrin α2 β1) have been supposed to play dominant roles in collagen-induced aggregation. However, there are arguments about the role of each receptor, especially the role of GPIa/IIa, and the crosstalk between receptors. Recently, we reported that the Ca2+ signaling produced by rhodocytin, which had been first reported to be an agonist for the collagen receptor GPIa/IIa, produced much less Ca2+ signaling in CHS platelets than in normal ones, whereas that produced by GPVI activators was normal. These suggest that GPIa/IIa or the rhodocytin-associated pathway is impaired in CHS platelets. CHS platelets are valuable to reassess the mechanism of collagen-dependent signal transduction system and to delineate the inter-relationship among collagen receptors.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 64 (9), 751-760, 2002
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206426178944
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- NII Article ID
- 110003920935
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- NII Book ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD38XosFSku7k%3D
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 10458/1148
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- NDL BIB ID
- 6311835
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- PubMed
- 12399597
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed