The α-Fetoprotein Level in the Sera of Bovine Fetuses and Calves

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  • 牛胎児および新生子牛血清中のα-フェトプロティン量
  • ウシ タイジ オヨビ シンセイ コウシ ケッセイチュウ ノ アルファ フェトプ

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Abstract

Bovine α-fetoprotein was isolated from bovine fetal serum by an immuno-chemical method. It was comfirmed that this protein was antigenically related to human α-fetoprotein. The levels of α-fetoprotein, albumin, transferrin, immunoglobulin and total proteins in the sera of developing bovine fetuses and calves were assayed by the single radial immuno-diffusion method. The maximum mean value of α-fetoprotein (6.14±0.61 mg/ml within a range of 5-8 mg/ml) was observed in the sera of 4-month fetuses. It decreased to 0.01-0.06 mg/ml at birth. The half-time of disappearance of α-fetoprotein after birth was estimated to be 2.52 days. Serum albumin, serum transferrin and total proteins increased successively with the development of fetuses. IgG was also detected from 4 (11%) of 36 fetal serum samples.

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