Unilateral Basement Membrane Zone Alteration of the Regenerated Laminar Region in Equine Chronic Laminitis
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- KUWANO Atsutoshi
- Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association
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- UENO Takanori
- Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association
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- KATAYAMA Yoshinari
- Epizootic Research Station (Tochigi-branch), Equine Research Institute, Japan Racing Association
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- NISHIYAMA Toshio
- Department of Tissue Physiology, Tokyo University of Agriculture and Technology
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- ARAI Katsuhiko
- Department of Tissue Physiology, Tokyo University of Agriculture and Technology
Bibliographic Information
- Other Title
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- 馬の慢性蹄葉炎罹患蹄の再生性葉状層における基底膜領域に見られた片側性構築異常
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Abstract
Between the laminar epidermis and the laminar dermis of laminar region (LR) in equine foot, it can be observed the basement membrane zone (BMZ), which is composed of a basement membrane and its accompaniments like the hemidesmosome and anchoring fibril. Alteration in the BMZ in equine laminitis is possibly related with not only development but also recovery outcome and recurrence of this disease. However, there is little known about the structure of the BMZ during the recovery phase of this disease. To assess the condition of the BMZ of LR affected by chronic laminitis, the tissue was examined in three cases at two weeks, four weeks and three months after the onset of laminitis, using pathological, immunohistochemical and electron microscopic techniques. Histologically in all laminitis cases, there was a regenerated laminar epidermis with proliferating keratinocytes between the Stratum medium and the dermis, but it included the undeveloped secondary epidermal laminae (ud-SELs) structure in one side of the primary epidermal laminae, especially in the part of the deep area of LR. Immunohistochemical results were positive for the anti-type IV collagen, anti-type VII collagen and anti-laminin 5 antibodies in the most BMZs. However, partial BMZs adjacent to the ud-SELs were negative for the anti-type VII collagen and anti-laminin 5 antibodies. Ultrastructurally, in the BMZ of the ud-SEL, the lamina densa and the lamina lucida were present. In contrast, the anchoring fibrils and the hemidesmosomes were either absent, or present at lower than normal levels. In conclusion, the present study indicated that the part of regenerated LR in chronic laminitis was not able to fully restore to construct the BMZ for a long time, especially in the unilateral side of laminar epidermis. It might be related with recurrence of this disease.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 67 (7), 685-691, 2005
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206426811904
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- NII Article ID
- 110003963792
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 7430705
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- PubMed
- 16082116
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed