Erythropoietin-Producing Cells in the Liver of ICR-Derived Glomerulonephritis (ICGN) Mice

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  • YAMAGUCHI-YAMADA Misuzu
    Laboratory of Neurophysiology, National Institute for Basic Biology
  • AKASHI Naotsugu
    Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
  • GOTO Yasufumi
    Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
  • ANAN Sayuri
    Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
  • YAMAMOTO Yoshie
    Department of Veterinary Sciences, National Institute of Infectious Diseases
  • OGURA Atsuo
    Bioresource Center, RIKEN
  • MANABE Noboru
    Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo

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Other Title
  • 遺伝性腎疾患モデル(ICGN)マウス肝臓におけるエリスロポエチン産生細胞の同定

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Abstract

The ICR-derived glomerulonephritis (ICGN) mouse is an appropriate model for anemia associated with chronic renal disorder (CRD). Insufficient renal production of erythropoietin (EPO) induces the anemia associated with CRD. EPO mRNA is expressed in both kidneys and liver of progressing-stage ICGN mice. Hypoxic stimulation induced the EPO mRNA expression in the liver as well as in the kidneys of ICGN mice. The localization of EPO-producing cells in the liver remains controversial. Present study using an amplified in situ hybridization technique identified that nonparenchymal cells were the source of hepatic EPO production in ICGN mice under both normoxia and hypoxia.<br>

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