実験的に作成したラット肺包虫症の磁気共鳴断層画像

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献22件
  • ASANUMA Taketoshi
    Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University
  • KAWAHARA Tokiko
    Laboratory of Pathobiology, Graduate School of Veterinary Medicine, Hokkaido University
  • INANAMI Osamu
    Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University
  • NAKAO Minoru
    Department of Parasitology, Asahikawa Medical College
  • NAKAYA Kazuhiro
    Animal Laboratory for Medical Research, Asahikawa Medical College
  • ITO Akira
    Department of Parasitology, Asahikawa Medical College
  • TAKIGUCHI Mitsuyoshi
    Laboratory of Pathobiology, Graduate School of Veterinary Medicine, Hokkaido University Department of Small Animal Clinic Science, School of Veterinary Medicine, Rakuno Gakuen University
  • HASHIMOTO Akira
    Laboratory of Pathobiology, Graduate School of Veterinary Medicine, Hokkaido University
  • KUWABARA Mikinori
    Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University

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タイトル別名
  • Magnetic Resonance Imaging of Alveolar Echinococcosis Experimentally Induced in the Rat Lung

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Pulmonary alveolar echinococcosis (AE) caused by the metacestode of Echinococcus multilocularis is a lethal zoonosis and is a lesion secondarily induced by hematogenous dissemination from hepatic AE lesions. In the present study, a hematogenous pulmonary AE model was experimentally induced in rats by the injection of echinococcal larval tissue homogenate to the tail vein, and then the pathological and diagnostic aspects of pulmonary AE were examined by magnetic resonance imaging (MRI). Histological primary, mature and degenerated AE lesions were observed 5, 18 and 50 weeks after injection, respectively. These lesions were discriminated as signal-void, hypointense and hyperintense regions in T1-weighted MRI (T1WI), respectively. The change in signal intensity in T1WI might reflect the content of proteinaceous fluid as a result of AE cyst degeneration. Western blot analysis of sera with antibodies of two epitopes (Em18 and Em16) of E. multilocularis provided evidence for AE infection in the early stage. T1WI in combination with Western blot analysis could possibility become definitive and early signs of hematogenous pulmonary AE infection.<br>

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