馬におけるミダゾラム-ケタミン-メデトミジン混合液持続点滴麻酔とセボフルラン麻酔の併用による麻酔効果および心血管系への影響

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献2件 参考文献48件
  • KUSHIRO Tokiko
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • YAMASHITA Kazuto
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • UMAR Mohammed Ahmed
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • MAEHARA Seiya
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • WAKAIKI Shinsuke
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • ABE Reona
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • SENO Takahiro
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • TSUZUKI Keiko
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • IZUMISAWA Yasuharu
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • MUIR William W.
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, The Ohio State University

書誌事項

タイトル別名
  • Anesthetic and Cardiovascular Effects of Balanced Anesthesia Using Constant Rate Infusion of Midazolam-Ketamine-Medetomidine with Inhalation of Oxygen-Sevoflurane (MKM-OS Anesthesia) in Horses

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抄録

The anesthetic sparring and cardiovascular effects produced by midazolam 0.8 mg/ml-ketamine 40 mg/ml-medetomidine 0.05 mg/ml (0.025 ml/kg/hr) drug infusion during sevoflurane in oxygen (MKM-OS) anesthesia was determined in healthy horses. The anesthetic sparring effects of MKM-OS were assessed in 6 healthy thoroughbred horses in which the right carotid artery was surgically relocated to a subcutaneous position. All horses were intubated and ventilated with oxygen using intermittent positive pressure ventilation (IPPV). The end-tidal concentration of sevoflurane (ETSEV) required to maintain surgical anesthesia was approximately 1.7%. Heart rate and mean arterial blood pressure averaged 23-41 beats/min and 70-112 mmHg, respectively. All horses stood between 23-44 min after the cessation of all anesthetic drugs. The cardiovascular effects of MKM-OS anesthesia were evaluated in 5 healthy thoroughbred horses ventilated using IPPV. Anesthesia was maintained for 4 hr at an ETSEV of 1.7%. Each horse was studied during left lateral (LR) and dorsal recumbency (DR) with a minimum interval between evaluations of 1 month. Cardiac output and cardiac index were maintained between 70-80% of baseline values during LR and 65-70% of baseline values during DR. Stroke volume was maintained between 75-85% of baseline values during LR and 60-70% of baseline values during DR. Systemic vascular resistance was not different from baseline values regardless of position. MKM-OS anesthesia may be useful for prolonged equine surgery because of its minimal cardiovascular depression in both of lateral and dorsal recumbency.<br>

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