Increased Generation of Superoxide in Erythrocytes infected with Babesia gibsoni.
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- OTSUKA Yayoi
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- YAMASAKI Masahiro
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- YAMATO Osamu
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- MAEDE Yoshimitsu
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Bibliographic Information
- Other Title
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- Increased generation of superoxide in erythrocytes infected with Bebesia gibsoni
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Abstract
The present study was conducted to clarify the mechanism underlying the oxidative process in erythrocytes infected with Babesia gibsoni. The parasite B. gibsoni was cultured together with erythrocytes from normal dogs for 7 days. When parasitemia reached 12.0-13.4% at Day 7, the production of superoxide in erythrocytes was significantly higher in the parasitized culture than in the control culture (p<0.005). The concentration of thiobarbituric acid reactive substances (TBARS) in erythrocytes in parasitized culture was also significantly increased compared with the control culture (p<0.005), indicating that lipid peroxidation was greater in infected erythrocytes than in non-infected cells. In addition, the rates of superoxide generation in the blood of B. gibsoni-infected dogs were also significantly higher than in non-infected dogs (p<0.001). These results indicate that superoxide anions are increased in erythrocytes parasitized with B. gibsoni, and suggest that oxidative damage, due to lipid peroxidation, might be caused in host erythrocytes by the parasite.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 63 (10), 1077-1081, 2001
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206427063296
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- NII Article ID
- 110003920751
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- NII Book ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXptVertrY%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 5953731
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- PubMed
- 11714022
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed