Postnatal Development of Glucose Transporter Proteins in Bovine Skeletal Muscle and Adipose Tissue.

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  • ABE Hiroyuki
    National Institute of Livestock and Grassland Sciences
  • KAWAKITA Yumi
    National Institute of Livestock and Grassland Sciences
  • HODATE Kyoko
    National Institute of Livestock and Grassland Sciences
  • SAITO Masayuki
    Laboratory of Biochemistry, Graduate School of Veterinary Medicine, Hokkaido University

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Facilitated diffusion of glucose across the plasma membrane is mediated by a family of glucose transporter (GLUT). GLUT1 is ubiquitously present in all tissues and involved in cellular glucose uptake, while GLUT4 plays a key role in cellular glucose uptake stimulated by insulin in skeletal muscles and adipose tissue. To examine the postnatal change in the GLUTs of ruminants, the protein levels of GLUT1 and GLUT4 were measured by Western blot analysis of skeletal muscles, adipose tissue and brain of Holstein male calves aged from 0 to 12 months. Analysis of rumen short chain volatile fatty acids revealed that rumen fermentation increased around 2-3 months old. The GLUT1 level did not change in all tissues examined during the postnatal period, while the GLUT4 levels in skeletal muscle and subcutaneous adipose tissue decreased gradually, and at 12 month old, it was about 40% of those seen at 0 month old. These results are contrast to those in non-ruminant species, in which GLUT4 increases during postnatal development, and may be related to the insulin-resistance seen in adult ruminants.

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