Malignant Aortic Body Tumor in a Holstein Cow.

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  • 牛の悪性大動脈小体腫瘍
  • Malignant aortic body tumor in a Holste

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A malignant aortic body tumor was observed in a 5-year-old female Holstein cow. The neoplastic mass, of 22 × 17 × 15 cm in size, was located at the base of the left atrium, having irregular lobular structures. The tumor cells had slightly eosinophilic cytoplasm, and a round or oval nucleus. Metastasis was only present in the premediastinal lymph node. The tumor cells exhibited intense immunoreactivity for neuron-specific enolase (NSE) and synaptophysin, and were moderately positive for chromogranin A. Electron-microscopy revealed membrane-limited granules in the cytoplasm. The cultured cells were spindle in shape, and having projectional cytoplasm. They were intensely positive for NSE, synaptophysin, chromogranin A, and neurofilament (200 kD). Consequently, this case was diagnosed as a malignant aortic body tumor from the neuroecrodermal origin.

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