Expressions of Protein Oxidation Markers, Dityrosine and Advanced Oxidation Protein Products in Cisplatin-Induced Nephrotoxicity in Rats

DOI Web Site Web Site 被引用文献4件 参考文献23件
  • KIMOTO Yumi
    United Graduate School of Veterinary Science, Yamaguchi University Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
  • SUGIYAMA Akihiko
    Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
  • NISHINOHARA Masaaki
    Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
  • ASANO Atsushi
    Course of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University
  • MASUDA Aino
    Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
  • OCHI Tairin
    Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.
  • TAKEUCHI Takashi
    Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

この論文をさがす

抄録

The purpose of this study was to evaluate whether dityrosine and advanced oxidation protein products (AOPP) reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of dityrosine in kidneys and plasma AOPP concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin injection induced tubular injury on days 2-4 after injection and increased serum creatinine and BUN on days 3 and 4. On days 2-4, dityrosine was immunostained in the cytoplasm of damaged tubular cells, and their immunostaining intensity increased time-dependently. Plasma AOPP levels were significantly increased on days 3 and 4. These results suggest that expressions of dityrosine and AOPP were associated with the severity of renal injury and may be useful markers for the development of cisplatin-induced nephrotoxicity.<br>

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (23)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ