Anatomy: Histoplanimetrical study on the relationship between cellular kinetics of epithelial cells and proliferation of indigenous bacteria in the rat colon

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  • QI Wang-Mei
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • YAMAMOTO Kenkichi
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • YOKOO Yuh
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • MIYATA Hidenori
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • UDAYANGA Kankanam Gamage Sanath
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • KAWANO Junichi
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • YOKOYAMA Toshifumi
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • HOSHI Nobuhiko
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • KITAGAWA Hiroshi
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

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  • Histoplanimetrical Study on the Relationship between Cellular Kinetics of Epithelial Cells and Proliferation of Indigenous Bacteria in the Rat Colon

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The aim of this study was to clarify the regulatory effects of epithelial kinetics on indigenous bacterial proliferation in the large intestine. The lifespan, migration speed and proliferation rate of crypt epithelial cells in the initial 20% of the colon (proximal colon) and the 50% of the colon (middle colon) in bromodeoxyuridine-administrated rats were histoplanimetrically and chronologically compared. The proximal colon possessed well-developed mucosal folds and a large amount of indigenous bacteria which filled the crypt lumen, whereas no folds or bacteria were found to occupy the crypt lumen in the middle colon. The cell lifespans were 32.2, 42.5 and 33.6 hr in the apical and the basal parts of the mucosal folds of the proximal colon, and in the middle colon, respectively. The migration speeds were 4.2, 2.1 and 3.3 μm/hr, respectively, while the appearance frequencies of proliferating cell nuclear antigen (PCNA)-positive crypt epithelial cells were 35.0, 24.6 and 33.8%. These findings suggest that the lifespan was shortened and the migration speed increased in the most luminal mucosa of colon, contributing to the elimination of the adhered bacteria from the most luminal mucosa. By contrast, the elongation of the lifespan and deceleration of the migration of epithelial cells in the basal parts of the mucosal folds might contribute to reliable settlement of indigenous bacteria, resulting in the maintenance of a large amount of indigenous bacteria in the lumen of the proximal colon.<br>

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