Internal medicine: Clinical use of D-dimer measurement for the diagnosis of disseminated intravascular coagulation in dogs
-
- MACHIDA Tatsuhiko
- Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
-
- KOKUBU Hiromitsu
- Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
-
- MATSUDA Kenji
- Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
-
- MIYOSHI Kenjirou
- Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
-
- UCHIDA Eiji
- Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
書誌事項
- タイトル別名
-
- Clinical Use of D-Dimer Measurement for the Diagnosis of Disseminated Intravascular Coagulation in Dogs
この論文をさがす
抄録
We measured the plasma D-dimer (DD) concentration in 205 dogs. Simultaneously, fibrinogen/fibrin degradation products (FDPs) concentration, platelet (PLT) count, prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma concentrations of fibrinogen (Fib) were measured in the same dogs. From these results, we were able to divide the animals into four groups: control (healthy dogs, n=18), pre-disseminated intravascular coagulation (preDIC) (n=20), disseminated intravascular coagulation (DIC) (n=21), and other (n=146). Significant differences in plasma DD concentration were found among the four groups: control, 0.45 ± 0.46 μg/ml (reference range, 0-1.37); preDIC, 5.0 ± 4.8 μg/ml; DIC, 16.3 ± 12.2 μg/ml; and other, 1.5 ± 2.7 μg/ml. A weak positive correlation (r=0.62) was found between FDPs and DD concentrations in the DIC group. As a DIC diagnostic test, the PLT/APTT/FDPs/DD combination had the highest accuracy of 100%, with a sensitivity of 73% and a specificity of 97%. We propose the use of FDPs and DD concentrations as part of the DIC diagnostic test panel, with DD and FDPs to provide accurate diagnosis.<br>
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 72 (10), 1301-1306, 2010
公益社団法人 日本獣医学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206428675712
-
- NII論文ID
- 130000264217
-
- NII書誌ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL書誌ID
- 10878873
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可