CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice
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- HONG Yu Ri
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
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- LEE Hyun
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
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- PARK Min Hee
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
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- LEE Jong Kil
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
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- LEE Ju Youn
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
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- SUH Hwa Deok
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
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- JEONG Min Seock
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
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- BAE Jae-Sung
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
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- JIN Hee Kyung
- Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
Bibliographic Information
- Other Title
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- Laboratory Animal Science : CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice
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Abstract
Niemann-Pick type C disease (NP-C) is a rare and ultimately fatal lysosomal storage disorder with variable neurologic symptoms. Loss of neuronal function and neuronal cell death occur in the NP-C brain, similar to the findings for other neurodegenerative diseases. Targeting of neuronal cells in the brain therefore represents a potential clinical intervention strategy to reduce the rate of disease progression and improve the quality of life. We previously reported that bone marrow stem cells show a neurogenic effect through CCL2 (also known as monocyte chemoattractant protein-1, MCP-1) secretion in the brains of NP-C mice. However, the direct effect of CCL2 on neurogenesis has not been ascertained. Here, to define neurogenic effects of CCL2 in NP-C, we applied human recombinant CCL2 to neural stem cells (NSCs) derived from NP-C mice. CCL2-treated NSCs showed significantly increased capacity for self-renewal, proliferation and neuronal differentiation. Similar results were observed in the subventricular zone of NP-C mice after CCL2 treatment. Furthermore, infusion of CCL2 into the NP-C mouse brain resulted in reduction of neuroinflammation. Taken together, our results demonstrate that CCL2 is a potential new therapeutic agent for NP-C.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 77 (6), 693-699, 2015
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206428684544
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- NII Article ID
- 130005085854
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 026576427
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- PubMed
- 25715651
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed