Establishment and Biological Characterization of Canine Histiocytic Sarcoma Cell Lines

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  • AZAKAMI Daigo
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • BONKOBARA Makoto
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • WASHIZU Tsukimi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • IIDA Akiko
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • KONDO Mari
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • KATO Rina
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • NIIKURA Yumiko
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • IWAKI Shuko
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
  • TAMAHARA Satoshi
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • MATSUKI Naoaki
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • ONO Kenichiro
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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Other Title
  • 犬の組織球性肉腫に由来する新たな細胞株の樹立とその性状解析

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Seven novel cell lines from canine histiocytic sarcoma (HS), three of which were disseminated cutaneous HS and four of which were synovial HS, were established. All of the established cell lines had the same morphological (by light and electron microscopic findings), cytochemical (α-naphthyl butyrate esterase-positive), and immunohistochemical (vimentin- and lysozyme-positive, and cyto-keratin-negative) characteristics as the original HS tumor cells. All of the established cell lines injected into nude mice subcutaneously produced solid tumors. Because the established cell lines also showed phagocytic and processing activities, the HS tumor cells appear to originate from the mononuclear phagocytic system cells, despite their differences in locations or organs.<br>

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