成長因子がIn vitroにおける胎子膵島B細胞の発達に及ぼす影響
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- YASUDA Masahiko
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- YAMAMOTO Masako
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- OCHIAI Hideharu
- Research Institute of Bioscience, School of Veterinary Medicine, Azabu University
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- EGUCHI Yasunobu
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- ARISHIMA Kazuyoshi
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
書誌事項
- タイトル別名
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- Effects of Growth Factors on Development of Fetal Islet B-Cells In Vitro
- Anatomy: Effects of growth factors on development of fetal islet B-cells in vitro
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抄録
To investigate the role of growth factors (epidermal growth factor [EGF], betacellulin, and activin A) in the development of islet B cells of rat fetal pancreatic explants in vitro, pancreases from rat fetuses at day 18 of gestation were cultured for 96 hr, with or without these growth factors. Culture medium was changed every 24 hr, and the level of insulin released in the culture medium was measured. After 72 hr of culture, pancreases were examined histologically. As a result, EGF promoted cell proliferation, but reduced B cell volume. Whereas, betacellulin and activin A inhibited cell division, but promoted increased B cell volume and insulin secretion, especially activin A, which stimulated insulin release in a time dependent manner. These results suggest that EGF, betacellulin, and activin A promote pancreatic cell proliferation, islet B-cell differentiation, and islet B-cell differentiation and functional maturation, respectively, and that EGF, betacellulin, and activin A, in this order, regulate islet B-cell neogenesis.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 69 (8), 807-811, 2007
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428789888
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- NII論文ID
- 110006401705
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 8929551
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可