Internal Medicine : FDG Uptake of Normal Canine Brain Assessed by High-Resolution Research Tomography-Positron Emission Tomography and 7 T-Magnetic Resonance Imaging

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  • KANG Byeong-Teck
    Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361–763, South Korea
  • SON Young-Don
    Neuroscience Research Institute, Gachon University of Medicine and Science Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 405–760, South Korea
  • LEE Sang-Rae
    The National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) The National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Chungbuk 363–883, South Korea
  • JUNG Dong-In
    Research Institute of Life Sciences, Gyeongsang National University Research Institute of Life Sciences, Gyeongsang National University, Jinju 660–701, South Korea
  • KIM Dong-Eog
    Molecular Imaging and Neurovascular Research (MINER) Laboratory, Dongguk University Ilsan Hospital Molecular Imaging and Neurovascular Research (MINER) Laboratory, Dongguk University Ilsan Hospital, Goyang 410–773, South Korea
  • CHANG Kyu-Tae
    The National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) The National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Chungbuk 363–883, South Korea
  • CHO Zang-Hee
    Neuroscience Research Institute, Gachon University of Medicine and Science Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 405–760, South Korea
  • PARK Hee-Myung
    Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143–701, South Korea

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  • FDG Uptake of Normal Canine Brain Assessed by High-Resolution Research Tomography-Positron Emission Tomography and 7 T-Magnetic Resonance Imaging

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The purpose of this study was to assess the normal distribution of 18F-fluoro-2-deoxy-D-glucose (FDG) uptake of canine brain structures using a high-resolution research tomography-positron emission tomography (HRRT-PET) and 7 T-magnetic resonance imaging (MRI) fusion system. FDG-PET and T2-weighted MRI of the brain were performed on 4 healthy laboratory beagle dogs. On MRI, regions of interests (ROIs) were manually drawn over 51 intracranial structures, including nine gross structures and 42 detailed structures. Relative standard uptake value ratio (rSUV=SUV of ROI/SUV of whole brain) was calculated for each ROI. The HRRT-PET and 7 T-MRI fusion imaging system demonstrated significant differences in glucose metabolism among various intracranial structures. Among gross structures, the midbrain and the pons and medulla oblongata had the highest uptake (rSUV: 1.12 ± 0.03) and lowest uptake (rSUV: 0.90 ± 0.06) of FDG, respectively. When rSUVs were calculated on detailed regions, the caudal colliculus and the longitudinal fibers of pons had the highest (rSUV: 1.62 ± 0.05) and the lowest (rSUV: 0.63 ± 0.03) glucose metabolism, respectively. Because the high resolution of PET-MRI fusion images provided clearly identifiable metabolic activities of canine brain, the HRRT-PET and 7 T-MRI fusion imaging might be a good tool for evaluation of intracranial diseases in canines.

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