国内で分離された野外株の攻撃に対する豚繁殖・呼吸障害症候群(PRRS)ワクチンの効果

DOI 日本農学文献記事索引 Web Site Web Site 参考文献57件
  • OKUDA Yo
    JA Zen-noh (National Federation of Agricultural Cooperative Associations), Institute of Animal Health
  • KURODA Maho
    JA Zen-noh (National Federation of Agricultural Cooperative Associations), Institute of Animal Health
  • ONO Masaaki
    JA Zen-noh (National Federation of Agricultural Cooperative Associations), Institute of Animal Health
  • CHIKATA Sumiko
    JA Zen-noh (National Federation of Agricultural Cooperative Associations), Institute of Animal Health
  • SHIBATA Isao
    JA Zen-noh (National Federation of Agricultural Cooperative Associations), Institute of Animal Health

書誌事項

タイトル別名
  • Efficacy of Vaccination with Porcine Reproductive and Respiratory Syndrome Virus Following Challenges with Field Isolates in Japan
  • Virology: Efficacy of vaccination with porcine reproductive and respiratory syndrome virus following challenges with field isolates in Japan

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The objective of this study was to evaluate the influences of genetic and antigenic variations in field isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on vaccine efficacy. Four-week-old pigs were vaccinated with a commercial modified live virus vaccine. Four weeks after vaccination, pigs in both the vaccinated group and the non-vaccinated group were challenged intranasally with 107 TCID50 of PRRSV wt-11 (Experiment 1) or PRRSV wt-7 (Experiment 2). Based on genome sequencing of ORF5 and cross neutralization test results, PRRSV wt-11 is similar to the vaccine strain, whereas wt-7 is distinct from the vaccine strain. In the vaccinated challenged groups, clinical signs were less severe, the mean rate of weight gain was greater, and gross lung lesions were less severe when compared with the non-vaccinated challenged groups in both experiments. In Experiment 1, the virus was isolated from serum at 3 days post-challenge, and the mean virus titers in broncho-alveolar lavage fluids (BALF) and tissues were lower in pigs in the vaccinated challenged groups compared with those in the non-vaccinated challenged group. In Experiment 2, virus isolation from serum, BALF and tissues showed no significant differences between the groups. These results suggest that commercial PRRSV vaccine could be effective in reducing clinical disease following a challenge with field isolates of PRRSV. However, with regards to virological protection, the efficacy of the vaccine may be affected by the nature of the PRRSV isolates.<br>

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