Laboratory Animal Science : New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia

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  • KONNO Kenjiro
    Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo, Kita-ku, Kyoto 603–8555, Japan Institute of Advanced Technology, Kyoto Sangyo University, Kamigamo, Kita-ku, Kyoto 603–8555, Japan
  • ITANO Naoki
    Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo, Kita-ku, Kyoto 603–8555, Japan Institute of Advanced Technology, Kyoto Sangyo University, Kamigamo, Kita-ku, Kyoto 603–8555, Japan
  • OGAWA Teppei
    NATSUME SEISAKUSHO Co., Ltd., 7–18 Saitoasagi-7, Ibaraki-shi Osaka 567–0085, Japan
  • HATAKEYAMA Mika
    AVS Co., Ltd., Shinjuku San-ei Bldg. 5th Fl., 1–22–2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160–0023, Japan
  • SHIOYA Kyoko
    Laboratory of Animal Experiment and Medicine Management, National Cerebral and Cardiovascular Center, 5–7–1 Fujishiro-dai, Suita, Osaka 565–8565, Japan
  • KASAI Noriyuki
    Center for Laboratory of Animal Research, Tohoku University, 2–1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980–8575, Japan

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  • New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia

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Appropriate and effective anesthesia is critical, because it has a strong influence on laboratory animals, and its affect greatly impacts the experimental data. Inhalational anesthesia by endotracheal intubation is currently prevailing in general anesthesia and is prefered over injection anesthesia, especially for large laboratory animals, because it is a safe and easy control agent. However, it is not common for small laboratory animals, because of the high degree of technical skills required. We assessed the capability of use for mice of the endotracheal intubation by using the endoscope system “TESALA AE-C1” and inhalational anesthesia using a ventilator. Endotracheal intubation was successfully performed on all 10 C57BL/6 mice injected with M/M/B: 0.3/4/5 comprised of medetomidine, midazoram and butorphanol, at a dose of 0.3 mg/kg + 4.0 mg/kg + 5.0 mg/kg body weight/mouse, respectively. After the intubated mice were connected with the inhalational anesthesia circuit and the ventilator, vital signs were measured until 15 min after the connection. The data with M/M/B: 0.3/4/5 showed stable and normal values, which indicated that this new endotracheal intubation method was simple, reliable and safe, which mean that this anesthesia is favorable in regard to the animal’s welfare.

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