Anesthetic Effect of a Combination of Medetomidine-Midazolam-Butorphanol in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)
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- OCHI Takehiro
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- NISHIURA Ippei
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- TATSUMI Mitsuyoshi
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- HIRANO Yoshimi
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- YAHAGI Kouichi
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- SAKURAI Yasuhiro
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- MATSUYAMA-FUJIWARA Kanako
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- SUDO Yuji
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- NISHINA Noriko
- Drug Safety Research Labs, Astellas Pharma Inc., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
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- KOYAMA Hironari
- Laboratory Animal Science Div., Astellas Research Technologies Co., Ltd., 1–6 Kashima 2-chome, Yodogawa-ku, Osaka 532–8514, Japan
Bibliographic Information
- Other Title
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- Laboratory Animal Science : Anesthetic Effect of a Combination of Medetomidine-Midazolam-Butorphanol in Cynomolgus Monkeys (Macaca fascicularis)
- Anesthetic effect of a combination of medetomidine-midazolam-butorphanol in cynomolgus monkeys (Macaca fascicularis)
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Abstract
The anesthetic effect of a combination of medetomidine, midazolam and butorphanol (Me-Mi-Bu) was evaluated in healthy cynomolgus monkeys. The Me-Mi-Bu combination was intramuscularly administered as follows: Dose 1, Me 0.015 mg/kg-Mi 0.1 mg/kg-Bu 0.15 mg/kg; Dose 2, Me 0.02 mg/kg-Mi 0.15 mg/kg-Bu 0.2 mg/kg; and Dose 3, Me 0.04 mg/kg-Mi 0.3 mg/kg-Bu 0.4 mg/kg. The combination rapidly induced immobilization, and lateral recumbency was reached within 15 min. The duration of anesthesia for each dose administered was follows: Dose 1, 47 ± 27 min; Dose 2, 113 ± 31 min; and Dose 3, 190 ± 24 min. The anesthetic effect of the combination was abolished by the α2-adrenoceptor antagonist atipamezole. No marked changes in the levels of hematologic or serum biochemical parameters were noted in cynomolgus monkeys administered the combination plus atipamezole. Taken together, these results suggest that the Me-Mi-Bu combination exhibits reversible anesthetic effect and may be useful for studies involving cynomolgus monkeys.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 76 (6), 917-921, 2014
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206429748352
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- NII Article ID
- 130003391295
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- NII Book ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC2cvpt1ehuw%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 025618471
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- PubMed
- 24584083
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed