Anatomy : Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells

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  • HAYASHI Kazuhiko
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • KUSAKABE Ken Takeshi
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan Laboratory of Veterinary Anatomy, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • SUGIMOTO Satoko
    Laboratory of Veterinary Anatomy, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • WAKITANI Shoichi
    Laboratory of Veterinary Biochemistry and Molecular Biology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889–2192, Japan
  • SUGI Shinji
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • KUNIYOSHI Nobue
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • HIYAMA Masato
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • TAKESHITA Ai
    Laboratory of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Osaka 598–8531, Japan
  • KANO Kiyoshi
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan Laboratory of Veterinary Anatomy, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan
  • KISO Yasuo
    Laboratory of Basic Veterinary Science, the United Graduate School of Veterinary Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan Laboratory of Veterinary Anatomy, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753–8515, Japan

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  • Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells

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The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance.

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