Anethole inhibits growth of recently emerged multidrug resistant toxigenic <i>Vibrio cholerae</i> O1 El Tor variant strains <i>in vitro</i>

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  • ZAHID M. Shamim Hasan
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598–8531, Japan
  • AWASTHI Sharda Prasad
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598–8531, Japan
  • HINENOYA Atsushi
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598–8531, Japan
  • YAMASAKI Shinji
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598–8531, Japan

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  • Public Health : Anethole inhibits growth of recently emerged multidrug resistant toxigenic Vibrio cholerae O1 El Tor variant strains in vitro
  • Anethole inhibits growth of recently emerged multidrug resistant toxigenic <italic>Vibrio cholerae</italic> O1 El Tor variant strains <italic>in vitro</italic>
  • Anethole inhibits growth of recently emerged multidrug resistant toxigenic Vibrio  cholerae O1 El Tor variant strains in vitro

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Abstract

To search natural compounds having inhibitory effect on bacterial growth is important, particularly in view of growing multidrug resistant (MDR) strains of bacterial pathogens. Like other bacterial pathogens, MDR Vibrio cholerae, the causative agent of diarrheal disease cholera, is becoming a great concern. As an approach of searching new antimicrobial agents, here, we show that anethole, a well-studied natural component of sweet fennel and star anise seeds, could potentially inhibit the growth of MDR O1 El Tor biotype, the ongoing 7th cholera pandemic variant strains of toxigenic V. cholerae. The minimum inhibitory concentration (MIC) of anethole against diverse O1 El Tor biotype strains is evaluated as 200 µg/ml. Moreover, the effect of anethole is bactericidal and exerts rapid-killing action on V. cholerae cells. This study is the first report which demonstrates that anethole, purified from natural compound, is a potent inhibitor of growth of toxigenic V. cholerae. Our data suggest that anethole could be a potential antimicrobial drug candidate, particularly against MDR V. cholerae mediated infections.

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