Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-<i>Lepr</i><sup><i>fa</i></sup> (SDT Fatty) Rats

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  • YAMAGUCHI Takayuki
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • SASASE Tomohiko
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • MERA Yasuko
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • TOMIMOTO Daisuke
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • TADAKI Hironobu
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • KEMMOCHI Yusuke
    Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 23 Naganuki, Hadano, Kanagawa 257–0024, Japan
  • OHTA Takeshi
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
  • SATO Eimei
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Faculty of Agriculture, Tohoku University, 1–1 Amamiya-machi, Tsutsumi-dori, Aoba-ku, Sendai 981–8555, Japan
  • MATSUSHITA Mutsuyoshi
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan

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  • Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Lepr[fa] (SDT Fatty) Rats

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Abstract

Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.

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