犬正常組織と乳腺腫瘍におけるBRCA1スプライシングバリアントmRNAの発現パターン

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献47件
  • SUGIURA Takaaki
    Laboratory of Veterinary Radiology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • MATSUYAMA Satoshi
    Laboratory of Veterinary Radiology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • AKIYOSI Hideo
    Laboratory of Advanced Diagnosis and Treatment, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • TAKENAKA Shigeo
    Laboratory of Molecular Biology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • YAMATE Jyoji
    Laboratory of Veterinary Pathology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • KUWAMURA Mitsuru
    Laboratory of Veterinary Pathology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • AOKI Mica
    Laboratory of Veterinary Surgery, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • SHIMADA Terumasa
    Laboratory of Veterinary Surgery, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • OHASHI Fumihito
    Laboratory of Veterinary Surgery, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • KUBO Kihei
    Laboratory of Veterinary Radiology, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

書誌事項

タイトル別名
  • Expression Patterns of the BRCA1 Splicing Variants in Canine Normal Tissues and Mammary Gland Tumors

この論文をさがす

抄録

Human BRCA1 is familial breast cancer susceptibility gene. Recently, decreased BRCA1 mRNA and protein expression has been identified in sporadic breast tumors. In the reported human BRCA1 splicing variants, delta11b lacks the majority of exon11 and is suspected to have a distinct function in normal tissues. The splicing variants display a variety of expression pattern in breast cancer samples. Although mammary gland tumor is important disease in dog, there are few reports for BRCA1 in the canine tumors. In this study, we examined the relative amounts of BRCA1 splicing variants mRNA in canine normal and mammary tumor samples by RT-PCR to investigate whether there is the altered expression of variant mRNAs in the canine tumor as reported in human. The exon11b-defecting RT-PCR products were observed in all the normal tissues examined and the nucleotide sequence was quite similar to that of human BRCA1 delta11b. In some tumor samples, we did not detect the products targeted for exon10-13 and exon14-15, while these products were observed in all the normal samples examined. Especially, the relative amounts of the exon11-defecting products were remarkably decreased in most of the tumors (11/16).<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (47)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ