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Immunohistochemical Detection of Phosphatidylserine and Thrombospondin on Denucleating Erythroblasts in Rat Bone Marrow
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- YOKOYAMA Toshifumi
- Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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- ETOH Takahiko
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- UDAYANGA Kankanam Gamage Sanath
- Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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- TAKAHARA Eiichiro
- Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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- QI Wang-Mei
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- WARITA Katsuhiko
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- MATSUMOTO Yoshiki
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- MIKI Takanori
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- TAKEUCHI Yoshiki
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- HOSHI Nobuhiko
- Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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- KITAGAWA Hiroshi
- Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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Description
The hypothesis that apoptotic factors play some roles in the denucleation of erythroblasts has been confirmed by the immunohistological detection of both phosphatidylserine and thrombospondin as phagocytosis-inducing factors in general apoptotic events. Both phosphatidylserine and thrombospondin were detected on the surface of cell membrane of mature erythroblasts, while thrombospondin was also detected in more immature erythroblasts. The intensities of their immune reactions increased as the erythroids matured. During denucleation, the positivities of both phosphatidylserine and thrombospondin were restricted on the surface of the cell membrane surrounding the protruding nuclei. Thus, the apoptotic process involves denucleation of erythroblasts and phosphatidylserine, and thrombospondin acts as phagocytosis-inducing factors in the denucleation event.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 73 (7), 949-952, 2011
JAPANESE SOCIETY OF VETERINARY SCIENCE
