Canine Serum Thermostable Alkaline Phosphatase Isoenzyme From a Dog With Hepatocellular Carcinoma

DOI JASI Web Site Web Site PubMed 2 Citations 30 References
  • FUKUI Yu-ichi
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • SATO Jun
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University Tomizawa Animal Hospital
  • SATO Reeko
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • YASUDA Jun
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • NAITO Yoshihisa
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

Bibliographic Information

Other Title
  • 肝細胞癌のイヌに認められた耐熱性アルカリフォスファターゼアイソザイム

Search this article

Abstract

A dog histopathologically diagnosed with hepatocellular carcinoma (HCC) showed very high serum alkaline phosphatase (ALP) activity. A supernatant of ascitic fluid and tumor tissue extracted from the dog also showed much higher ALP activity than normal. ALP isoenzyme analysis of samples was perfomed using polyacrylamide gel disk electrophoresis, and a wide, broad abnormal band was observed. By various treatments, the abnormal band showed thermostability, which is a characteristic of tumor-associated ALP that has only been reported in humans. The thermostable ALP isoenzyme was not found in sera from 39 dogs with several types of tumor that originated from the liver, except for HCC, nor was it found in 10 dogs with hepatic diseases that did not include hepatic tumors. The thermostable ALP isoenzyme seemed to be associated with canine HCC.<br>

Journal

Citations (2)*help

See more

References(30)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top