Maternal Exposure to Low Doses of DES Altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring
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- NISHIKAWA Osamu
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- ARISHIMA Kazuyoshi
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- KOBAYASHI Tetsuo
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- SHIRAI Mitsuyuki
- Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University
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- MURAKAMI Masaru
- Department of Molecular Biology, School of Veterinary Medicine, Azabu University
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- SAKAUE Motoharu
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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- YAMAMOTO Masako
- Department of Anatomy II, School of Veterinary Medicine, Azabu University
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Abstract
Our previous studies demonstrated that prenatal diethylstilbestrol (DES) treatment disrupts steroidogenesis but induces high-level expression of androgen receptor (AR) mRNA to inhibit the disruption of spermatogenesis. This study examined which prenatal DES treatment influenced hepatic microsomal enzymes, CYP3A1, CYP2B1/2, CYP2C11, UGT2B1 (UDP-glucuronosyltransferase 2B1), and IGF-1 (insulin-like growth factor-1), in male rat offspring. DES treatment decreased the mRNA expression levels of CYP3A1 and CYP2B1/2, but did not alter the expression of CYP2C11. At 6 weeks, DES treatment increasd the mRNA expression levels of UGT2B1 and IGF-1. These results suggest that prenatal DES treatment alters two hepatic enzymes (CYP3A1 and CYP2B1/2) and IGF-1 mRNA expression levels to counteract the low level of testosterone, but this disrupted UGT2B1 mRNA expression reduces the testosterone level.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 74 (2), 247-253, 2012
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206430636672
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- NII Article ID
- 130001190598
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- NII Book ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC383nsV2isw%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 023551631
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- PubMed
- 21959891
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed