Propagation of Swine Hemagglutinating Encephalomyelitis Virus and Pseudorabies Virus in Dorsal Root Ganglia Cells

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  • HARA Yoko
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
  • HASEBE Rie
    Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University
  • SUNDEN Yuji
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
  • OCHIAI Kenji
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
  • HONDA Eiichi
    Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology
  • SAKODA Yoshihiro
    Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
  • UMEMURA Takashi
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University

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  • Pathology: Propagation of swine hemagglutinating encephalomyelitis virus and pseudorabies virus in dorsal root ganglia cells

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Abstract

Swine hemagglutinating encephalomyelitis virus (HEV) causes encephalomyelitis or vomiting and wasting disease in suckling piglets. Neurotoropism of the virus has been demonstrated in previous in vivo studies. In the present study, we investigated the infectivity and propagation of HEV in comparison with those of pseudorabies virus (PRV), another neurotropic virus, using dorsal root ganglia cells of newborn mice containing nerve cells and non-neuronal cells. HEV infected nerve cells but did not infect non-neuronal cells, whereas PRV infected both cell types. By using cytoskeletal inhibitors, it was suggested that propagation of HEV and PRV within and among nerve cells depended on microtubules and intermediate filaments of nerve cells, indicating that the viruses may be transported between the cell body and axonal terminals of neurons by fast axonal flow.<br>

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