Pathology: Possible origin of CSF antibodies induced by intrathecal immunization and prophylactic effects against intracerebral rabies virus infection
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- AOSHIMA Keisuke
- Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
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- SUNDEN Yuji
- Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
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- ISHIDA Sachiyo
- Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
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- OCHIAI Kenji
- Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
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- UMEMURA Takashi
- Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
書誌事項
- タイトル別名
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- Possible Origin of CSF Antibodies Induced by Intrathecal Immunization and Prophylactic Effects against Intracerebral Rabies Virus Infection
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説明
Intrathecal (IT) immunization involves injecting antigens directly into the intraventricular or subarachnoid spaces, or brain, to induce antigen-specific antibodies (Ab) in the cerebrospinal fluid (CSF). In the present study, rabbits were immunized IT with inactivated rabies virus to investigate the origins of CSF Ab. The time course of Ab induction and tumor necrosis factor-alpha expression suggested the possibility that the CSF Ab originated in the serum. In addition, Ab-producing cells infiltrated around the blood vessels of the brain, suggesting local production of Ab within the central nervous system (CNS). Furthermore, subcutaneous (SC) immunization prior to IT immunization induced a rapid and magnified Ab response in the CSF compared with IT immunization alone. These results were confirmed by the fact that mice immunized SC prior to IT were more resistant to intracerebral challenge with rabies virus than mice immunized via the IT route alone. Taken together, these results suggest that combined SC and IT immunization is a more effective vaccination protocol for prophylaxis and treatment of rabies.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 73 (10), 1303-1308, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431168640
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- NII論文ID
- 130000868202
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 11291555
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- PubMed
- 21646749
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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