Pathology: Possible origin of CSF antibodies induced by intrathecal immunization and prophylactic effects against intracerebral rabies virus infection

  • AOSHIMA Keisuke
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
  • SUNDEN Yuji
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
  • ISHIDA Sachiyo
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
  • OCHIAI Kenji
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University
  • UMEMURA Takashi
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Hokkaido University

書誌事項

タイトル別名
  • Possible Origin of CSF Antibodies Induced by Intrathecal Immunization and Prophylactic Effects against Intracerebral Rabies Virus Infection

この論文をさがす

説明

Intrathecal (IT) immunization involves injecting antigens directly into the intraventricular or subarachnoid spaces, or brain, to induce antigen-specific antibodies (Ab) in the cerebrospinal fluid (CSF). In the present study, rabbits were immunized IT with inactivated rabies virus to investigate the origins of CSF Ab. The time course of Ab induction and tumor necrosis factor-alpha expression suggested the possibility that the CSF Ab originated in the serum. In addition, Ab-producing cells infiltrated around the blood vessels of the brain, suggesting local production of Ab within the central nervous system (CNS). Furthermore, subcutaneous (SC) immunization prior to IT immunization induced a rapid and magnified Ab response in the CSF compared with IT immunization alone. These results were confirmed by the fact that mice immunized SC prior to IT were more resistant to intracerebral challenge with rabies virus than mice immunized via the IT route alone. Taken together, these results suggest that combined SC and IT immunization is a more effective vaccination protocol for prophylaxis and treatment of rabies.<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (20)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ