Pathology: Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs
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- OGAWA Mizue
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- UCHIDA Kazuyuki
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- PARK Eun-Sil
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- KAMISHINA Hiroaki
- Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University
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- SASAKI Jun
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- CHANG Hye-Sook
- Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University
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- YAMATO Osamu
- Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University
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- NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
書誌事項
- タイトル別名
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- Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs
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Immunohistochemistry was performed to assess whether oxidative stress and/or denatured proteins play roles in the pathogenesis of canine degenerative myelopathy (DM). Two Pembroke Welsh Corgi (PWC) dogs with a homozygous mutation (c.118G>A) in the canine superoxide dismutase 1 (SOD1) gene were examined. The pathological features of the dogs were consistent with those of previous cases of DM in PWC. In the spinal lesions, diffuse SOD1 expression was observed in the neurons while no inclusion-like aggregates had formed, which disagreed with the findings of a previous study. A unique inducible nitric oxide synthase (iNOS) staining pattern in reactive astrocytes and a significant increase in ubiquitin immunoreactivity in the spinal lesions were also observed. These findings indicate the involvement of oxidative stress and the accumulation of ubiquitinated proteins in the pathogenesis of canine DM, whereas the role of SOD1 remains unclear.<br>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 73 (10), 1275-1279, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431175168
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- NII論文ID
- 130000868053
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 11291498
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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