Induction of a Th-1-Biased IgG Subclass Response against Equine Herpesvirus Type 1 in Horses Previously Infected with Type 4 Virus
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- BANNAI Hiroshi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- TSUJIMURA Koji
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- KONDO Takashi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- NEMOTO Manabu
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- YAMANAKA Takashi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- SUGIURA Takeo
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- MAEDA Ken
- Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
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- MATSUMURA Tomio
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
Bibliographic Information
- Other Title
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- Virology: Induction of a Th-1-biased IgG subclass response against equine herpesvirus type 1 in horses previously infected with type 4 virus
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Abstract
An immunoglobulin G (IgG) subclass response against equine herpesvirus type 1 (EHV-1) infection was investigated in horses that were naïve to EHV-1/4 and those that had previously been exposed to EHV-4. The IgG subclass response was determined by an ELISA using EHV-1-specific recombinant gG protein as an antigen. In most horses naïve to EHV-1/4, IgGa, IgGb, and IgG(T) were induced after experimental infection with EHV-1. In contrast, a subclass response dominated by IgGa and IgGb, with no apparent increase in IgG(T), was observed after EHV-1 infection in horses previously infected with EHV-4. Horses naturally infected with EHV-1 in the field showed similar responses. These results indicated that pre-infection with EHV-4 induced a Th-1-biased IgG subclass response against subsequent EHV-1 infection.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 73 (4), 535-539, 2011
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Keywords
Details 詳細情報について
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- CRID
- 1390001206431256448
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- NII Article ID
- 130000444586
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 11104919
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed