シクロスポリンは犬の単核球におけるIL-2,IL-4およびIFN-γのmRNA発現を抑制するが,TNF-αは抑制しない

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献4件 参考文献54件
  • KOBAYASHI Tetsuro
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • MOMOI Yasuyuki
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • IWASAKI Toshiroh
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

書誌事項

タイトル別名
  • Cyclosporine A Inhibits the mRNA Expressions of IL-2, IL-4 and IFN-.GAMMA., but not TNF-.ALPHA., in Canine Mononuclear Cells
  • Internal medicine: Cyclosporine A inhibits the mRNA expressions of IL-2, IL-4 and IFN-γ, but not TNF-α, in canine mononuclear cells
  • Internal medicine Cyclosporine A inhibits the mRNA expressions of IL 2 IL 4 and IFN g but not TNF a in canine mononuclear cells
  • Cyclosporin A inhibits the mRNA expressions of IL-2, IL-4 and IFN-γ, but not TNF-α, in canine mononuclear cells

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抄録

The effects of the calcineurin inhibitors cyclosporine A (CsA) and FK506 on the mRNA expressions of various cytokines were evaluated in dogs to determine whether the effects of CsA and FK506 in dogs were similar to those in humans. The mRNA expression levels of the cytokines IL-2, IL-4, IFN-γ and TNF-α were measured in PHA-stimulated canine PBMC using real-time RT-PCR after incubation with CsA or FK506 for 5 hr. Both reagents inhibited IL-2, IL-4 and IFN-γ mRNA expressions in a dose-dependent manner. However, CsA hardly inhibited the mRNA expression of TNF-α. These findings are important for assessing the indications of CsA treatment in dogs.<br>

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