Immunology: Dietary supplementation with a probiotic fermented four-herb combination enhances immune activity in broiler chicks and increases survivability against Salmonella Gallinarum in experimentally infected broiler chicks
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- JUNG Bock-Gie
- College of Veterinary Medicine, Chonnam National University
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- KO Jae-Hyung
- College of Veterinary Medicine, Chonnam National University
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- LEE Bong-Joo
- College of Veterinary Medicine, Chonnam National University
書誌事項
- タイトル別名
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- Dietary Supplementation with a Probiotic Fermented Four-Herb Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks
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抄録
Herbs including Curcuma longa, Houttuynia cordata, Prunus mume and Rubus coreanus have potential immune enhancing and antimicrobial effects. Probiotics also have antibacterial effects, and some are important in regulating the immune system. The aims of the present study were to evaluate the immune enhancing effects of a probiotic fermented four-herb combination (PFH) in broiler chicks and to demonstrate the prophylactic effect of PFH against Salmonella Gallinarum in experimentally infected broiler chicks as an initial step towards the development of feed supplements for promotion of immune activity and disease prevention. Continuous ingestion of PFH markedly increased lysozyme activity in serum and the spleen, peripheral blood mononuclear cell (PBMC) proliferation, the CD4+:CD8+ T lymphocyte ratio in the spleen and antibody production level in broiler chicks. Conversely, prostaglandin E2 synthesis in serum and PBMC culture medium was significantly decreased in the PFH-fed chicks compared with the control group in a dose-dependent manner. In the chicks experimentally infected with S. Gallinarum, mortality was delayed in the 2% PFH-fed chicks. Moreover, the survival rates in the 2% PFH-fed group remained the highest among all the trial groups throughout the experimental period. Taken together, these findings suggest that PFH enhances immune activity in broiler chicks and increases survivability against Salmonella Gallinarum in experimentally infected broiler chicks, likely because of potent stimulation of nonspecific immune responses.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 72 (12), 1565-1573, 2010
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431357440
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- NII論文ID
- 130000307686
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BC3MXhtlOgu78%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10954243
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- PubMed
- 20675965
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可