Pathology: Prognostic significance of surgical margin, ki-67 and cyclin D1 protein expression in grade 2 canine cutaneous mast cell tumor
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- OZAKI Kiyokazu
- Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University
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- YAMAGAMI Tetsushi
- Marupi Lifetech Co., Ltd.
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- NOMURA Koji
- Marupi Lifetech Co., Ltd.
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- NARAMA Isao
- Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University
書誌事項
- タイトル別名
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- Prognostic Significance of Surgical Margin, Ki-67 and Cyclin D1 Protein Expression in Grade II Canine Cutaneous Mast Cell Tumor
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The prognosis for canine cutaneous mast cell tumor (CCMT) is thought to be correlated with histopathological grading. However, the wide variety of histopathologic types of grade II is one of the most troublesome and difficult points for prognosis. The objective of this study is to determine the prognostic value of surgical margin, ki-67 and cyclin D1 protein expression in grade II tumor. Surgically resected specimens of solitary grade II CCMT from 48 dogs with follow-up periods over 360 days (median was 1080 days) were used in this study. The expression of cyclin D1 and ki-67 proteins was determined by morphometrically using slides stained immunocytochemically, and the correlations among the results, survival rate, and recurrence and/or metastasis rate of each dog were analyzed statistically. The recurrence and/or metastasis and mortality rate in the incomplete surgical excision group within 30 months postoperatively were higher than that of the complete surgical excision group. In the incomplete surgical excision group, dogs with low positive staining of ki-67 had a significantly better survival, but the recurrence and metastasis rate and ki-67 positivity failed to show a significant correlation. Only a small number of cases showed cyclin D1-positive tumor cells, but most of them had a poor outcome with a high recurrence rate. In grade II CCMT, incomplete excision induced a relatively high metastasis rate and poor prognosis. Ki-67 positivity is a marker for the estimation of overall survival in incomplete surgical excision cases. Cyclin D1 positivity was low and may not have a prognostic role.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 69 (11), 1117-1121, 2007
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431387648
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- NII論文ID
- 130000447601
- 110006452647
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 9281983
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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