Anatomy: Immunohistochemical study on the delayed progression of epithelial apoptosis in follicle-associated epithelium of rat Peyer's patch
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- ONISHI Sachiko
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- MIYATA Hidenori
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- INAMOTO Tetsurou
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- QI Wang-Mei
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- YAMAMOTO Kenkichi
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- YOKOYAMA Toshifumi
- Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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- WARITA Katsuhiko
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- HOSHI Nobuhiko
- Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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- KITAGAW Hiroshi
- Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
書誌事項
- タイトル別名
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- Immunohistochemical Study on the Delayed Progression of Epithelial Apoptosis in Follicle-Associated Epithelium of Rat Peyer's Patch
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抄録
It is well known that some caspases in apoptosis is involved in determinant of terminal differentiation and maturation of various cells. Our previous study ultrastructurally clarified the differentiation into M cells from immature microvillous epithelial cells and the redifferentiation from M cells to microvillous epithelial cells in the follicle-associated epithelium (FAE) of rat Peyer's patch. In this study, the difference of epithelial apoptosis between the FAE of Peyer's patch and intestinal villi was immunohistochemically investigated in rat jejunoileum. As a result, cleaved caspase-3 was limited to several epithelial cells at the tip of FAE, whereas almost all of the epithelial cells were cleaved caspase-3 positive in intestinal villi. Cleaved caspase-9 was detected only in a few exfoliating or exfoliated epithelial cells of both FAE and intestinal villi. Nuclear DNA-fragmentation was detected only in several epithelial cells of the tip of FAE, while it was expressed from the middle regions in the intestinal villi. The DNase I expression of the epithelial cytoplasm was much weaker in FAE than in intestinal villi. Bcl-x expression was restricted in the apical cytoplasms of epithelial cells in the FAE, whereas it was restricted in whole cytoplasms in villous epithelial cells. These findings suggest that the progression of the apoptotic process in the epithelial cells of FAE is later than in the intestinal villi, so that the possibility of epithelial differentiation might be remained in the FAE, unlike in the intestinal villi.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 69 (11), 1123-1129, 2007
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431389184
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- NII論文ID
- 10020031398
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 9281998
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可