Effectiveness of CPAP Therapy for Patients with Sleep Apnea Syndrome Undergoing Coronary Arterial Bypass Grafting

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  • Sezai Akira
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Akahoshi Toshiki
    Department of Respiratory Medicine, Nihon University School of Medicine
  • Minami Kazutomo
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Sekino Hisakuni
    Sekino Hospital
  • Hata Mitsumasa
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Yoshitake Isamu
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Wakui Shinji
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Unosawa Satoshi
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Takasaka Ayako
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Murakami Tomohiko
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Shiono Motomi
    Department of Cardiovascular Surgery, Nihon University School of Medicine
  • Uchiyama Makoto
    Department of Psychiatry, Nihon University School of Medicine
  • Akashiba Tsuneto
    Department of Respiratory Medicine, Nihon University School of Medicine Department of Sleep Medicine, Nihon University School of Medicine

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Other Title
  • 睡眠時無呼吸症候群を合併した冠動脈バイパス術後患者に持続的気道内陽圧 (CPAP) 療法が著効した症例
  • 症例報告 睡眠時無呼吸症候群を合併した冠動脈バイパス術後患者に持続的気道内陽圧(CPAP)療法が著効した症例
  • ショウレイ ホウコク スイミンジ ムコキュウ ショウコウグン オ ガッペイ シタ カンドウミャク バイパス ジュツゴ カンジャ ニ ジゾクテキ キドウ ナイ ヨウアツ CPAP リョウホウ ガ チョコウ シタ ショウレイ

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Abstract

Two males (aged 51 and 66 years) underwent emergent coronary artery bypass grafting for acute myocardial infarction. After surgery, they were diagnosed with severe sleep apnea syndrome (SAS) and left ventricular dysfunction. They were treated for SAS with continuous positive airway pressure (CPAP) therapy. After the CPAP therapy, these two patients not only improved their left ventricular function but also decreased the levels of A and B-type natriuretic peptides, renin-angiotensin-aldsterone indices, high sensitivity CRP, and oxidative LDL. SAS is common in cardiovascular disease and is a potential cause of increased mortality. The deteriorative effects of SAS on cardiac function have recently received attention because SAS has been found to increase cardiac afterload, stimulate sympathetic nerve activity, and induce myocardial ischemia. We conclude that CPAP therapy for SAS patients with left ventricular dysfunction is effective for left ventricular function, RAAS hormones, catecholamine, inflammation and oxidative stress.

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