Current Topics on Side Effects of Iodine-containing X-ray Contrast Agents and Gadolinium-containing MRI Contrast Agents

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  • ヨード造影剤やＧｄキレート剤の副作用に係る今日的諸問題

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Diagnostic imaging modalities have evolved significantly with the development of iodine-containing X-ray contrast media and gadolinium-based MRI contrast agents. Gadolinium-containing contrast media are widely employed as a contrast agent for MRI and have been generally considered to be safe. Nephrogenic systemic fibrosis has been reported as a severe progressive disorder related to the administration of gadolinium-chelate agents in patients with renal insufficiency, since 2006. NSF causes fibrosis of the skin and connective tissue throughout the body. The exact pathophysiolosy of NSF remains uncertain and no clearly effective therapies exist for NSF so far. Since 2007, the FDA has asked manufactures to include a boxed warning on the product labeling of all gadolinium-based MR contrast agents. In this article, we introduce the nephrogenic systemic fibrosis in addition to iodine-containing contrast induced nephropathy.

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