Age Influence on Cardiac Enzyme Induction by Pyrogen Stimulation

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A comparative study was made of the metabolism of cardiac muscle of young and adult rats after the injection of pyrogen, using as indices the activities of succinate dehydrogenase and NADH2-cytochrome C reductase. The results showed a tendency of tricarboxylic acid cycle enzyme activity in cardiac muscle of young rats to increase while, in contrast, a decrease was observed on older animals, following challenge with pyrogen.

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