<133><SUP>X</SUP>eによる胃内循環動態の研究,とくに疾患腎の胃内血流分布について

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  • Studies of the Intrarenal Distribution of Blood Flow with <133><SUP>X</SUP>e in Diseased Human Kidney
  • 133Xeによる腎内循環動態の研究,とくに疾患腎の腎内血流分布について
  • 133Xe ニ ヨル ジンナイ ジュンカン ドウタイ ノ ケンキュウ , トクニ シッカンジン ノ ジンナイ ケツリュウ ブンプ ニ ツイテ

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In order to study the distribution of the blood flow in diseased human kidney, 133xenon clearance curves were obtained from the patients with chronic renal disease and hypertension. The results obtained from the <133>xenon clearance curves were compared with those determined by the dye dilution method. Materials and Methods Observations were made in 34 kidneys of the patients including 21 chronic glomerulonephritis, 8 essential hypertension, 4 chronic pyelonephritis and I suspected polyarteritis nodosa. Through the catheter inserted into one renal artery, 1-5 mci of 133xenon dissolved in isotonic saline was injected and the clearance curve of 133xenon from the kidney was monitored externally by a scintillation probe positioned perpendicularly to the back for 30 to 45 minutes. The output of the probe was led to a ratemeter and thence to a printer. The counts per second were plotted against time on semilogarithm graph and the curves were analyzed graphically into several exponential components. The flow per unit mass of tissue (flow rate) and the percentage of the total renal blood flow (flow ratio) for each of these components were calculated. In 10 patients dye dilution curves were recorded and analyzed by the method introduced by TAKEUCHI and ISHIKAWA. The relationships between the results derived from 133xenon clearance curves recorded for 30 minutes and the values of blood urea nitrogen, RBF calculated from CCPH (RBFPAH), Cthio and of maximal urinary osmolality determined on Fishberg's concentration test were studied. Results The clearance curves of 133xenon recorded for 45 minutes were all resolved into 4 components, while 3 components were recognized in the curves recorded for 30 minutes. In the kidneys with normal function, the mean values of the flow rate and the flow ratio in component I and III calculated from the 30 minutes curves coincided closely with those of component I and IV obtained from the 45 minutes curves, respectively. The mean value of the flow rate of component II in the 30 minutes curves was similar to the average of those of component II and III in the 45 minutes curves. Analyzing in the same curves, statistically significant correlations were observed between the values of component I and III from the 30 minutes record and those of component I and IV from the 45 minutes record, respectively. Also, there was significant correlation between component II from the 30 minutes record and the average of component II and III from the 45 minutes record in the flow ratio but not in the flow rate.

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