Immnohistochemical Study of Nude Mouse-transplantable Human Malignant Fibrous Histiocytoma of the Maxilla.

DOI
  • MORI Atsushi
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • TAGAWA Toshiro
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • INUI Madoka
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • NOMURA Jouji
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • FUKUMORI Tetsuya
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • SEKI Yutaka
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • TAGAWA Shinya
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University
  • OHSE Syusaku
    Department of Oral and Maxillofacial Surgery, School of Medicine, Mie University

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Other Title
  • ヌードマウス可移植性ヒト上顎由来悪性線維性組織球腫累代株の免疫組織化学的検討

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Abstract

An immunohistochemical study was performed on paraffin sections of human malignant fibrous histiocytoma (MFH) grafted into nude mice and original tumor. Original tumor was pleomorphic MFH of the maxilla. Both original and grafted tumor cells expressed vimentin and histiocytic (macrophage) marker CD68 (KP1). A small part of the original tumor reacted with another anti-histiocyte monoclonal antibody (MAb) MAC387, and a few cells expressed HLA-DR. However, the grafted tumor lacked reactivity for these antibodies. Neither the original nor grafted tumor reacted with the anti-leukocyte common antigen MAb. Expression of CD68 suggested that this tumor is histiocytic in origin. However, other immunoreactivity results did not strongly support this hypothesis.

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