99mTc phytate sentinel node lymphoscintigraphy in oral cancer patients

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  • TSUCHIMOCHI Makoto
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • HAYAMA Kazuhide
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • ODA Takaaki
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • SUE Mikiko
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • KATADA Tsutomu
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • SASAKI Yoshihiko
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • TOYAMA Michio
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • KUROIWA Hajime
    Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata
  • YAMAGUCHI Akira
    Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Dentistry at Niigata
  • MATAGA Izumi
    Department of Oral and Maxillofacial Surgery II, The Nippon Dental University School of Dentistry at Niigata
  • TSUCHIKAWA Kozoh
    Department of Oral and Maxillofacial Surgery I, The Nippon Dental University School of Dentistry at Niigata

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Other Title
  • ｀９９ｍ´Ｔｃ　ｐｈｙｔａｔｅを用いた口腔癌のセンチネルリンパ節シンチグラフィ
  • 99mTc phytate オ モチイタ コウクウガン ノ センチネルリンパセツ シンチグラフィ

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Due to the lack of information regarding sentinel lym phoscintigraphy (SLS) in the head and neck regions using 99m Tc phytate, the kinetics and visualization of this pharmaceutical in SLS have not been well understood. We report the results of SLS using 99mTc phytate in pa tientswith oral squamous cell carcinoma. SLS studies were performed in eight patients with oral squamous cell carcinoma (tongue 7, and lower gingiva 1): 74 MBq of 99mTc phytate was injected in the periphery of the tumor; after injection, static images in frontal and lateral projections of the head and neck were taken at 1, 2, 4, 6, and 24 hours with a 10-minute acquisition time. SPECT images were also studied. The intensity of accumulation in lymphatic nodes was represented by a hot node to background activity ratio (HN/BG ratio) for the region of interest. Thirty-one, 29, 30, 27, and 16 hot nodes were visualized by SLS at 1, 2, 4, 6, and 24 hours after injec tionin eight patients respectively. Nine sentinel lymph nodes were identified out of 11 hot nodes in SLS 4 hours later in three NO patients (mean: 3.0 sentinel nodes). The HN/BG ratios were 8.76±5.62, 7.07±4.38, and 3.15±1.71 at 2, 4, and 24 hours after injection in eight patients respectively. SLS using 99mTc phytate successfully im agedsentinel nodes in patients with oral squamous cell carcinoma. The radiopharmaceutical accumulation in lymphatic nodes was higher at 2 and 4 hours than at 24 hours after injection (p<0.05).

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