Daily concurrent preoperative chemoradiotherapy using superselective intra-arterial infusion via superficial temporal artery for advanced oral cancer

DOI
  • MITSUDO Kenji
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • YAMAMOTO Noriyuki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • SHIGETOMI Toshio
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • NISHIGUCHI Hiroaki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • FURUE Hiroki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • IWAI Toshinori
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • HIROTA Makoto
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • MATSUI Yoshiro
    Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University
  • UEDA Minoru
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • TOHNAI Iwai
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

Bibliographic Information

Other Title
  • 進行口腔癌に対する浅側頭動脈よりの超選択的動注法を用いた連日同時放射線化学療法
  • ―腫瘍栄養動脈による頸部転移リンパ節への病理組織効果―
  • —Histological evaluation of metastatic cervical lymph nodes—

Abstract

Superselective intra-arterial chemotherapy via a superficial temporal artery has become feasible for daily concurrent radiotherapy and chemotherapy in patients with oral cancer. In this study, histopathological effects on metastatic cervical lymph nodes in cases of advanced oral cancer using superselective intra-arterial chemoradiotherapy were evaluated. Thirty-seven oral cancer patients with cervical lymph node metastasis were treated with preoperative chemoradiotherapy using superselective intra-arterial infusion via the superficial temporal artery. The treatment consisted of superselective intra-arterial infusions (docetaxel, total 60 mg/m2; cisplatin, total 100-150 mg/m2) and concurrent radiotherapy (total 40-60 Gy) for 4-6 weeks, followed by surgery. In cases in which the catheter was inserted into the facial artery, grade III or IV (Oboshi-Shimosato classification) in the cervical lymph node metastasis was obtained in 20 (83.3%) of 24 patients. And, forty-six (88.5%) of 52 metastatic lymph nodes showed grade III or IV. This method was an effective regimen for oral cancer with cervical lymph node metastasis.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001206435821184
  • NII Article ID
    130004555738
  • DOI
    10.11277/stomatology.59.1
  • ISSN
    21850461
    00290297
  • Text Lang
    en
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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