書誌事項
- タイトル別名
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- Clinical significance of platelet activation ratio, plasma interleukin-18 and high sensitivity C-reactive protein in patients with sleep apnea syndrome
- スイミンジ ムコキュウ ショウコウグン カンジャ ニ オケル カッセイカ ケッショウバン ヒリツ ト ケッチュウ インターロイキン 18 コウカンド CRP ソクテイ ノ リンショウテキ イギ
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Introduction: Hypoxia in sleep apnea syndrome (SAS) worsens arteriosclerosis, hypertension and vascular diseases. Disease severity of SAS is correlated with platelet function and various cytokines. To clarify the evidence, we analyzed the platelet activation, interleukin-18 (IL-18), and high sensitivity C-reactive protein (hs-CRP) in SAS patients.<BR>Materials and Methods: Sixty-six patients were divided into four groups (non-SAS, SAS-mild, SAS-moderate and SAS-severe) with the apnea-hypopnea index (AHI). Platelet activation was examined by CD62P positive platelets analyzed by flow cytometry. Plasma levels of IL-18 and hs-CRP were measured by ELISA and Behring Nepherometer II in each patient.<BR>Results: Activated platelet ratio in PRP showed a hight endency in SAS-moderate and SAS-severe, as compared with the non-SAS group. Plasma level of IL-18 was significantly high in SAS-severe, as compared with the non-SAS group.<BR>Conclusion: In the SAS patients, activated plateletratio in PRP and plasma level of IL-18 was useful as an index reflecting the disease severity of SAS. However, there were no significant differences between activated platelet ratio in whole blood, hs-CRP level and the disease severity of SAS.
収録刊行物
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- 日本口腔科学会雑誌
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日本口腔科学会雑誌 57 (3), 261-266, 2008
特定非営利活動法人 日本口腔科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206435989248
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- NII論文ID
- 130004335989
- 10021952892
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- NII書誌ID
- AN00189050
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- ISSN
- 21850461
- 00290297
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- NDL書誌ID
- 9616580
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可