Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland

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  • IKARI Tatsuya
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • SUGIURA Tsuyoshi
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • HIRAKI Akimitsu
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • SEKI Katsuhiro
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • SHIRASUNA Kanemitsu
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University

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Other Title
  • マウス唾液腺の分枝形成における肝細胞増殖因子（ＨＧＦ）の関与
  • マウス ダエキセン ノ ブンシ ケイセイ ニ オケル カン サイボウ ゾウショク インシ HGF ノ カンヨ

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The involvement of hepatocyte growth factor (HGF) in salivary gland (SG) branching morphogenesis was investigated. The mouse submandibular gland (SMG) starts to develop at embryonic days 11.5-12 (E11.5-12), and branching morphogenesis occurs in the area between the mandibular bone and tongue between E14 and E16.5. Real-time RT-PCR showed that the expres sionof the c-met/HGF receptor gene in SMG increased and peaked between E14 and E16.5, concomitant with epithelial branching, and high levels of HGF mRNA were detected in the surrounding mesenchyme at E14-E15.5. Experiments with serum-free organ cultures demonstrated that the branching morphogenesis of SMG is regulated by interactions with the surrounding mesen chymederived HGF and c-met expression in SMG, which occur concomitant with epithelial branching. The data obtained also suggest that the HGF that is released tran sientlyfrom tongue muscles may contribute to the rapid development of SMG at the branching stage.

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